Merusi sent an email to supporters Sunday afternoon.
Merusi had pulled nomination papers for a Selectmen seat last week.
There are two seats up for election in April.
Current Selectmen Chair Dennis Giombetti announced in December, he would not for another term.
"I have decided not to solicit the necessary signatures for the nomination," wrote Merusi in an email to supporters Sunday.
"The last 48 yours have been spent reviewing with some of you the strategies and time requirements needed to advance a responsible campaign. With my retirement, the next 10 weeks will be spent on an aggressive and ongoing management transition for the 5 departments in my Division. This includes preparing staff for budget meetings with the various Town Boards and Committees and for Town Meeting. I also will need to initiate and complete the necessary financial planning for my personal finances. After the review and analysis, the realistic answer is that the majority of compromise on my time over the next 10 weeks would have to come from the campaign," wrote Merusi.
Nomination papers for town-wide office, including Selectmen, are due Tuesday, Jan. 14 at 5 p.m. to the Town Clerk's office.
Those who have taken out nomination papers, besides Merusi, included incumbent Selectman Laurie Lee, Cheryl Tully Stoll, Town Meeting member Dennis Paulsen, Doug Freeman, Deborah Butler and Ryan Gagne.
Lee, Tully Stoll, Butler and Paulsen have returned their papers to the Town Clerk's office as of Friday.
The Framingham Town Election is Tuesday, April 1.