The fire was reported at 209 Cochituate Rd in two-story structure with multi apartments.
Fire was showing from the home when crews arrived just after 8 a.m.
Framingham Fire had the fire under control within a half hour.
American Red Cross volunteers are assisting a family of five adults displaced by a fire, said Communication Manager Ashley Studley.
"Volunteers are providing the family with emergency temporary shelter at a hotel, emergency funds for food and comfort kits (toiletries). Two family members are receiving additional funds for clothing," she said.
No one was injured.
Updated with video at 11:13 a.m. Updated at 12:30 p.m. with Red Cross update. Updated again for Wednesday newsletter.